Dermatologic side effects have included skin breakouts (9 %) throughout medical research studies of lamivudine plus zidovudine administered as separate formulas. Pruritus has likewise been stated. Skin and nailbed coloring modifications, hazardous skin necrolysis, increased sweating, urticaria, and also leukocytoclastic vasculitis with eosinophilia and fever have been connected with zidovudine. Hardly ever, nail hyperpigmentation has actually been gone along with by mucocutaneous pigmentation or hypertrichosis. Alopecia, erythema multiforme, as well as Stevens-Johnson disorder have been stated throughout postmarketing experience with lamivudine, lamivudine-zidovudine, and/or zidovudine. [Ref]
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If the medication is discontinued, brownish-black or bluish discoloration of nails may develop throughout the very first month or two of zidovudine treatment and usually disappears within 2 months. Staining may take place as longitudinal streaks or transverse bands. [Ref]
Psychiatric side effects have actually included depressive disorders (9 %) throughout medical research studies of lamivudine plus zidovudine provided as different formulas. Various other psychological negative side effects stated with the usage of zidovudine have actually consisted of separated cases of mania, anxiousness, complication, loss of mental acuity, and also grandiosity. [Ref]
Cardiovascular adverse effects have actually included cardiomyopathy as well as vasculitis throughout postmarketing encounter with lamivudine-zidovudine, lamivudine, and/or zidovudine. [Ref]
Metabolic adverse effects have consisted of raised amylase (higher than 2 times ULN; 4.2 %) throughout scientific research studies of lamivudine plus zidovudine carried out as separate solutions. Redistribution/accumulation of physical body fat including central weight problems, dorsocervical fatty tissue augmentation, peripheral losing, face losing, breast augmentation, and "cushingoid look" have been noted in clients obtaining antiretroviral brokers. Progressive subcutaneous fat wasting has actually been stated. Hyperglycemia and redistribution/accumulation of physical body fat have been reported during postmarketing experience with zidovudine, lamivudine, and/or lamivudine-zidovudine.
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